Cosmic evolution of non-topological solitons, paper 1

Nontopological solitons are stable field configurations which may be formed in a primordial phase transition. Their cosmic evolution is studied, and the possibility that such objects could contribute significantly to the energy density of the Universe is examined. As the Universe cools, initially all but the largest lumps evaporate into free particles; those which survive may subsequently enter a brief accretion phase before they freeze out at a final size. Although the minimum critical charges which survive depend on particle masses and couplings, researchers develop an analysis which applies to a wide class of models. In most cases, solitons of moderate size survive the evaporation process only if there is a significant charge asymmetry or if they form at a temperature well below their binding energy per charge

On the Robustness of the Velocity Anisotropy Parameter in Probing the Stellar Kinematics in Milky Way-Like Galaxies: Takeaway from TNG50 Simulation

We analyze the velocity anisotropy of stars in real and energy space for a sample of Milky Way-like galaxies in the TNG50 simulation. We employ different selection criteria, including spatial, kinematic, and metallicity cuts, and make three halo classes ( A-C) that show mild-to-strong sensitivity to different selections. The above classes cover 48%, 16%, and 36% of the halos, respectively. We analyze the beta radial profiles and divide them into either monotonically increasing radial profiles or ones with peaks and troughs. We demonstrate that halos with monotonically increasing beta profiles are mostly from class A , while those with peaks/troughs are part of classes B and C . This means that care must be taken, as the observationally reported peaks/troughs might be a consequence of different selection criteria. We infer the anisotropy parameter beta energy space and compare that against the beta radial profile. It is seen than 65% of halos with very mild sensitivity to different selections in real space are those for which the beta radial and energy profiles are closely related. Consequently, we propose that comparing the beta radial and energy profiles might be a novel way to examine the sensitivity to different selection criteria and thus examining the robustness of the anisotropy parameter in tracing stellar kinematics. We compare simulated beta radial profiles against various observations and demonstrate that, in most cases, the model diversity is comparable with the error bars from different observations, meaning that the TNG50 models are in good overall agreement with observations

Vaccine delivery with microneedle skin patches in nonhuman primates

Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics into the skin, penetration of the stratum corneum is needed. Topically applied skin patches with micron-scale projections ('microneedles') pierce the upper layers of the skin and enable vaccines that are coated on or encapsulated within the microneedles to be dispersed into the skin. Although millimeter-scale syringes have shown promise for vaccine delivery in humans and technologies, such as the Dermaroller (Dermaroller, Wolfenbüttel, Germany), exist for creating microscale punctures in the skin for delivery of solutions of therapeutics, solid microprojection microneedles coated with dry vaccine formulations offer a number of valuable features for vaccination, including reduced risk of blood-borne pathogen transmission or needle-stick injury, the potential for vaccine administration by minimally trained personnel or even self administration and the use of solid-state vaccine formulations that may reduce or eliminate cold-chain requirements in vaccine distribution. Recent studies in mice have demonstrated the ability of microneedles to effectively deliver vaccines to the skin, eliciting protective immunity to influenza, hepatitis C and West Nile virus.Ragon Institute of MGH, MIT and HarvardMassachusetts Institute of TechnologyHarvard UniversityNational Institutes of Health (U.S.) (AI095109)National Institutes of Health (U.S.) (AI096040)National Institutes of Health (U.S.) (AI095985)National Institutes of Health (U.S.) (AI078526)National Institutes of Health (U.S.) (AI060354)United States. Dept. of Defense (Contract W911NF-07-D-0004

Signatures of Hierarchical Clustering in Dark Matter Detection Experiments

In the cold dark matter model of structure formation, galaxies are assembled hierarchically from mergers and the accretion of subclumps. This process is expected to leave residual substructure in the Galactic dark halo, including partially disrupted clumps and their associated tidal debris. We develop a model for such halo substructure and study its implications for dark matter (WIMP and axion) detection experiments. We combine the Press-Schechter model for the distribution of halo subclump masses with N-body simulations of the evolution and disruption of individual clumps as they orbit through the evolving Galaxy to derive the probability that the Earth is passing through a subclump or stream of a given density. Our results suggest that it is likely that the local complement of dark matter particles includes a 1-5% contribution from a single clump. The implications for dark matter detection experiments are significant, since the disrupted clump is composed of a `cold' flow of high-velocity particles. We describe the distinctive features due to halo clumps that would be seen in the energy and angular spectra of detection experiments. The annual modulation of these features would have a different signature and phase from that for a smooth halo and, in principle, would allow one to discern the direction of motion of the clump relative to the Galactic center.Comment: 26 pages, 18 figure

All's well that begins Wells: Celebrating 60 years of Animal Behaviour and 36 years of research on anuran social behaviour

The scientific study of frogs and toads as important systems in behavioural ecology traces its roots to an influential review published in this journal 36 years ago (Wells 1977a, ‘The social behaviour of anuran amphibians’, Animal Behaviour, 25, 666–693). In just 28 pages, Wells summarized the state of knowledge on important behaviours associated with anuran breeding and introduced an evolutionary framework ‘for understanding the relationship between social behaviour and ecology’ (page 666) that was largely lacking in earlier treatments of this group. Not only is Wells's review one of the most cited papers ever published in Animal Behaviour, it is also responsible for setting broad research agendas and shaping much of our current thinking on social behaviour in an entire order of vertebrates. As such, it is entirely appropriate that we honour Wells's review and its contributions to the study of animal behaviour in this inaugural essay celebrating 12 papers selected by the community as the most influential papers published in the 60-year history of Animal Behaviour. In our essay, we place Wells's review in historical context at the dawn of behavioural ecology, highlight the field's progress in answering some major research questions outlined in the review, and provide our own prospectus for future research on the social behaviour of anuran amphibians. Highlights ► This essay celebrates Kent Wells's (1977, Animal Behaviour, 25, 666–693) paper, ‘The social behaviour of anuran amphibians’. ► We place the article in historical context and outline its major contributions. ► We discuss progress on anuran social behaviour since its publication in 1977. ► We provide our own prospectus on the future of anuran behavioural ecology

Kepler and Kuiper (K&K): Addressing Key Questions in Astrophysics and Planetary Science

No abstract availabl

Inferring the Morphology of Stellar Distribution in TNG50: Twisted and Twisted-stretched Shapes

We investigate the morphology of the stellar distribution in a sample of Milky Way (MW) like galaxies in the TNG50 simulation. Using a local in shell iterative method (LSIM) as the main approach, we explicitly show evidence of twisting (in about 52% of halos) and stretching (in 48% of them) in the real space. This is matched with the re-orientation observed in the eigenvectors of the inertia tensor and gives us a clear picture of having a re-oriented stellar distribution. We make a comparison between the shape profile of dark matter (DM) halo and stellar distribution and quite remarkably see that their radial profiles are fairly close, especially at small galactocentric radii where the stellar disk is located. This implies that the DM halo is somewhat aligned with stars in response to the baryonic potential. The level of alignment mostly decreases away from the center. We study the impact of substructures in the orbital circularity parameter. It is demonstrated that in some cases, far away substructures are counter-rotating compared with the central stars and may flip the sign of total angular momentum and thus the orbital circularity parameter. Truncating them above 150 kpc, however, retains the disky structure of the galaxy as per initial selection. Including the impact of substructures in the shape of stars, we explicitly show that their contribution is subdominant. Overlaying our theoretical results to the observational constraints from previous literature, we establish fair agreement.Comment: 29 pages, 21 figures, Accepted for publication in Ap